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Proteintech

EXOSC10 Polyclonal Antibody, CoraLite® Plus 488

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Product Details

CL488-16731

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.40 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

EXOSC10 fusion protein Ag10189

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: IAEELPKEP QGIIACCNPV PPLVRQQINE MHLLIQQARE MPLLKSEVAA GVKKSGPLPS AERLENVLFG PHDCSHAPPD GYPIIPTSGS VPVQKQASLF PDEKEDNLLG TTCLIATAVI TLFNEPSAED SKKGPLTVAQ KKAQNIMESF ENPFRMFLPS LGHRAPVSQA AKFDPSTKIY EISNRWKLAQ VQVQKDSKEA VKKKAAEQTA AREQAKEACK AAAEQAISVR QQVVLENAAK KRERATSDPR TTEQKQEKKR LKISKKPKDP EPPEKEFTPY DYSQSDFKAF AGNSKSKVSS QFDPNKQTPS GKKCIAAKKI KQSVGNKSMS FPTGKSDRGF RYNWPQR

Target Information

About 50% of patients with polymyositis/scleroderma (PM-Scl) overlap syndrome are reported to have autoantibodies to a nuclear/nucleolar particle termed PM-Scl. Exosome component 10 (EXOSC10), also named autoantigen PM/Scl-2, is the 100 kDa antigen component of PM-Scl and is recognized by most sera of PM-Scl patients. EXOSC10 is strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. As a putative catalytic component ofthe RNA exosome complex which has 3'->5' exoribonuclease activity, EXOSC10 participates in a multitude of cellular RNA processing and degradation events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: autoantigen PM-SCL; Autoantigen PM/Scl 2; Autoantigen PM/Scl 2 homolog; Exosome complex component 10; exosome component 10; P100 polymyositis-scleroderma overlap syndrome-associated autoantigen; PM/Scl-100; Polymyositis/scleroderma autoantigen 100 kDa; Polymyositis/scleroderma autoantigen 2; Polymyositis/scleroderma autoantigen 2 homolog; unnamed protein product

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Gene Aliases: EXOSC10; p2; p3; p4; PM-Scl; PM/Scl-100; PMSCL; PMSCL2; RRP6; Rrp6p

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UniProt ID: (Human) Q01780, (Mouse) P56960

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Entrez Gene ID: (Human) 5394, (Mouse) 50912

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Function(s)
nucleotide binding 3'-5'-exoribonuclease activity nucleic acid binding RNA binding single-stranded RNA binding nuclease activity exonuclease activity exoribonuclease activity protein binding 3'-5' exonuclease activity hydrolase activity metal ion binding telomerase RNA binding catalytic activity 5'-3' exoribonuclease activity poly(A) RNA binding
Process(es)
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay maturation of 5.8S rRNA nuclear-transcribed mRNA catabolic process nucleobase-containing compound metabolic process rRNA processing RNA processing dosage compensation by inactivation of X chromosome cellular metabolic process nuclear mRNA surveillance CUT catabolic process nuclear polyadenylation-dependent rRNA catabolic process histone mRNA catabolic process nuclear retention of unspliced pre-mRNA at the site of transcription RNA phosphodiester bond hydrolysis, exonucleolytic exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) DNA repair RNA catabolic process cellular response to DNA damage stimulus regulation of gene expression regulation of nucleobase-containing compound metabolic process negative regulation of telomere maintenance via telomerase ribosomal small subunit biogenesis nuclear polyadenylation-dependent snoRNA catabolic process nuclear polyadenylation-dependent snRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent CUT catabolic process nuclear polyadenylation-dependent antisense transcript catabolic process polyadenylation-dependent snoRNA 3'-end processing regulation of telomerase RNA localization to Cajal body positive regulation of mRNA cis splicing, via spliceosome
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