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Product Details
11348-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
EXT2 Fusion Protein Ag1748 (369-718 aa encoded by BC010058) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.14 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: KMSDVYSIL QSIPQRQIEE MQRQARWFWE AYFQSIKAIA LATLQIINDR IYPYAAISYE EWNDPPAVKW GSVSNPLFLP LIPPQSQGFT AIVLTYDRVE SLFRVITEVS KVPSLSKLLV VWNNQNKNPP EDSLWPKIRV PLKVVRTAEN KLSNRFFPYD EIETEAVLAI DDDIIMLTSD ELQFGYEVWR EFPDRLVGYP GRLHLWDHEM NKWKYESEWT NEVSMVLTGA AFYHKYFNYL YTYKMPGDIK NWVDAHMNCE DIAMNFLVAN VTGKAVIKVT PRKKFKCPEC TAIDGLSLDQ THMVERSECI NKFASVFGTM PLKVVEHRAD PVLYKDDFPE KLKSFPNIGS L (369-718 aa encoded by BC010058)
Target Information
This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acetylglucosaminyltransferase; exostoses (multiple) 2; exostosin 2; Exostosin-2; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N; Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 2; Multiple exostoses protein 2 homolog; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; Putative tumor suppressor protein EXT2
Gene Aliases: AI893565; EXT2; SOTV; SSMS
UniProt ID: (Human) Q93063, (Mouse) P70428
Entrez Gene ID: (Human) 2132, (Mouse) 14043, (Rat) 311215
Molecular Function:
glycosyltransferase
ossification
mesoderm formation
glycosaminoglycan biosynthetic process
protein glycosylation
signal transduction
heparan sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
cell differentiation
cellular polysaccharide biosynthetic process
protein binding
acetylglucosaminyltransferase activity
glucuronosyltransferase activity
transferase activity, transferring glycosyl groups
heparan sulfate N-acetylglucosaminyltransferase activity
protein homodimerization activity
metal ion binding
protein heterodimerization activity
glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
transferase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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