|Tested species reactivity||Human, Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptides corresponding to a portion of amino acids 350-400 ofhuman EZH1.|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||2-4 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
This antibody is 86% homologous to rat and canine.
Suggested positive control: antigen standard for EZH1 (transient overexpression lysate), human or mouse spleen.
EZH1 is a human homolog of the Drosophila gene Enhancer of zeste E(z), a member of the polycomb group of transcriptional repressors. In mice, EZH1 is a regulator of homeotic gene expression implicated in the assembly of repressive protein complexes in chromatin. The strong sequence conservation between species suggests potential role for EZH1 in human development as a transcriptional regulator and as a component of protein complexes that stably maintain heterochromatin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2.
PA1-41114 was used in western blot to investigate DNA methylation profiles in small cell lung cancer, patient-derived xenografts, and cell lines at single-nucleotide resolution
|Poirier JT,Gardner EE,Connis N,Moreira AL,de Stanchina E,Hann CL,Rudin CM||Oncogene (34:5869)||2015|