Immunogen sequence: APETAVLGAE LSAVGENGGE KGKLVIFEGG TSRKGNAEPD PPVRLFQIHG NDKSNTKAVE VPAFASSLNS NDVFLLRTQA EHYLWYGKGS SGDERAMAKE LASLLCDGSE NTVAEGQEPA EFWDLLGGKT PYANDKRLQQ EILDVQSRLF ECSNKTGQFV VTEITDFTQD DLNPTDVMLL DTWDQVFLWI GAEANATEKE SALATAQQYL HTHPSGRDPD TPILIIKQGF EPPIFTGWFL AWDPNIWSAG KTYEQLKEEL GDAAAIMRIT ADMKNATLSL NSNDSEPKYY PIAVLLKNQN QELPEDVNPA KKENYLSEQD FVSVFGITRG QFAALPGWKQ LQMKKEKGLF; Positive Samples: Mouse lung, Rat lung
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Endothelin-1; ET-1; PPET1; preproendothelin; Preproendothelin-1
Gene Aliases: ARCND3; EDN1; ET-1; ET1; HDLCQ7; PPET1; preproET; QME