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          • Primary Antibodies ›
          • Endothelin 1 Antibodies

          Invitrogen

          Endothelin 1 Polyclonal Antibody

          View all (12) Endothelin 1 antibodies

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          Cite Endothelin 1 Polyclonal Antibody

          Additional Information:
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          Endothelin 1 Polyclonal Antibody

          Product Details

          PA5149583

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          0.04-0.4 µg/mL
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200-1:500
          -

          Immunocytochemistry (ICC/IF)

          0.25-2 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Recombinant protein corresponding to Human EDN1
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.3 mg/mL

          Amount

          30 µg

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.2, with 40% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_3709571

          Product Specific Information

          Immunogen sequence: PYGLGSPRSK RALENLLPTK ATDRENRCQC ASQKDKKCWN FCQAGKELRA EDIMEKDWNN H

          Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 71%.

          Target Information

          The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: Big endothelin 1; Big ET; Big ET 1; Big ET1; BigET; EDN1; Endothelin-1; Et; PPET1; Preproendothelin-1; unnamed protein product

          View more View less

          Gene Aliases: ARCND3; EDN1; ET1; HDLCQ7; PPET1; QME

          View more View less

          UniProt ID: (Human) P05305

          View more View less

          Entrez Gene ID: (Human) 1906

          View more View less

          Function(s)
          receptor binding cytokine activity hormone activity protein binding endothelin A receptor binding endothelin B receptor binding receptor agonist activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development patterning of blood vessels response to hypoxia in utero embryonic development histamine secretion response to amphetamine heart process glomerular filtration regulation of systemic arterial blood pressure by endothelin cardiac neural crest cell migration involved in outflow tract morphogenesis noradrenergic neuron differentiation transcription from RNA polymerase II promoter cellular calcium ion homeostasis regulation of pH smooth muscle contraction mitochondrion organization cell surface receptor signaling pathway G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling axon guidance heart development respiratory gaseous exchange body fluid secretion regulation of blood pressure positive regulation of cell proliferation response to xenobiotic stimulus dorsal/ventral pattern formation response to ozone positive regulation of heart rate gene expression positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy negative regulation of gene expression regulation of glucose transport neural crest cell development neural crest cell differentiation neural crest cell fate commitment response to activity artery smooth muscle contraction vein smooth muscle contraction regulation of vasoconstriction calcium-mediated signaling signal transduction involved in regulation of gene expression peptide hormone secretion nitric oxide transport negative regulation of blood coagulation positive regulation of cell migration neutrophil chemotaxis thyroid gland development neuron projection development positive regulation of prostaglandin biosynthetic process phospholipase D-activating G-protein coupled receptor signaling pathway positive regulation of prostaglandin secretion response to lipopolysaccharide response to testosterone negative regulation of smooth muscle cell apoptotic process response to prostaglandin F embryonic heart tube development response to nicotine intracellular signal transduction positive regulation of urine volume positive regulation of renal sodium excretion response to muscle stretch epithelial fluid transport vasoconstriction middle ear morphogenesis positive regulation of odontogenesis superoxide anion generation positive regulation of I-kappaB kinase/NF-kappaB signaling rhythmic excitation response to amino acid positive regulation of MAPK cascade protein kinase B signaling response to leptin cellular response to human chorionic gonadotropin stimulus leukocyte activation positive regulation of nitric oxide biosynthetic process positive regulation of cell size positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle contraction positive regulation of JNK cascade positive regulation of hormone secretion negative regulation of hormone secretion blood vessel morphogenesis positive regulation of smooth muscle cell proliferation axon extension positive regulation of calcium-mediated signaling cartilage development negative regulation of protein metabolic process membrane depolarization canonical Wnt signaling pathway maternal process involved in parturition positive regulation of sarcomere organization axonogenesis involved in innervation positive regulation of cell growth involved in cardiac muscle cell development pharyngeal arch artery morphogenesis positive regulation of chemokine-mediated signaling pathway renal sodium ion absorption cellular response to hydrogen peroxide ERK1 and ERK2 cascade calcium ion transmembrane transport cellular response to calcium ion cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to peptide hormone stimulus cellular response to glucocorticoid stimulus cellular response to mineralocorticoid stimulus cellular response to fatty acid cellular response to hypoxia cellular response to xenobiotic stimulus response to dexamethasone response to transforming growth factor beta cellular response to transforming growth factor beta stimulus glomerular endothelium development glomerular visceral epithelial cell differentiation endothelin receptor signaling pathway endothelin receptor signaling pathway involved in heart process positive regulation of neutrophil chemotaxis cellular response to toxic substance sympathetic neuron axon guidance regulation of blood vessel diameter cAMP/PKA signal transduction negative regulation of phospholipase C/protein kinase C signal transduction positive regulation of protein localization to nucleus positive regulation of NIK/NF-kappaB signaling response to salt semaphorin-plexin signaling pathway involved in axon guidance meiotic cell cycle process involved in oocyte maturation positive regulation of vascular smooth muscle cell proliferation positive regulation of artery morphogenesis
          It has to be done as per old AB suggested Products section.

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