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Invitrogen

Endothelin B Receptor Polyclonal Antibody

View all (10) Endothelin B Receptor antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
433BB748-DC81-4FE4-83AD-384F97313745 Created with sketchtool. Create Citation
C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
433BB748-DC81-4FE4-83AD-384F97313745 Created with sketchtool. Create Citation
C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support

Product Details

Tested Applications
Dilution
Immunohistochemistry (Paraffin) (IHC (P))
1:100-1:1000
Western Blot (WB)
1:500-1:3000
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 8 and 111 of Endothelin B Receptor
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2544649

Product Specific Information

PA5-27173 targets Endothelin B Receptor in Western Blot and Immunohistochemistry - Paraffin applications and shows reactivity with Human, mouse and Rat samples.

The PA5-27173 immunogen is a synthetic peptide corresponding to a region within amino acids 8 and 111 of Endothelin B Receptor.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Target Information

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.


⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Ednra; endothelin B receptor; Endothelin receptor non-selective type; endothelin receptor subtype B1; Endothelin receptor type B; endothelin-B receptor; ET-B; ET-BR; Etb; piebald

Gene Aliases: ABCDS; Ednra; EDNRB; ET-B; ET-BR; ETB; ETB1; ETBR; ETR-b; ETRB; HSCR; HSCR2; Sox10m1; WS4A

UniProt ID: (Human) P24530, (Rat) P21451, (Mouse) P48302

Entrez Gene ID: (Human) 1910, (Rat) 50672, (Mouse) 13618

Molecular Function: G-protein coupled receptor receptor

Function(s)
negative regulation of transcription from RNA polymerase II promoter neural crest cell migration positive regulation of protein phosphorylation regulation of pH cell surface receptor signaling pathway negative regulation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration nervous system development peripheral nervous system development posterior midgut development aging regulation of blood pressure positive regulation of cell proliferation negative regulation of neuron maturation response to organic cyclic compound vein smooth muscle contraction sensory perception of pain cGMP-mediated signaling melanocyte differentiation regulation of fever generation negative regulation of cellular protein metabolic process enteric smooth muscle cell differentiation positive regulation of urine volume positive regulation of renal sodium excretion epithelial fluid transport vasoconstriction vasodilation negative regulation of apoptotic process macrophage chemotaxis response to pain enteric nervous system development regulation of epithelial cell proliferation regulation of sensory perception of pain positive regulation of penile erection cellular response to lipopolysaccharide endothelin receptor signaling pathway G-protein coupled receptor signaling pathway response to lipopolysaccharide pigmentation developmental pigmentation signal transduction
Process(es)
endothelin receptor activity protein binding peptide hormone binding type 1 angiotensin receptor binding receptor activity G-protein coupled receptor activity signal transducer activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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