Percent identity with other species by BLAST analysis: Human, Dog (100%) Gorilla, Gibbon (95%) Monkey (89%) Marmoset (84%).
The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABCDS; EDNRB; Endothelin B receptor; Endothelin receptor non-selective type; endothelin receptor subtype B1; Endothelin receptor type B; ET-B; Et-b receptor; Et-b-r; ET-BR; ET-RB; ETB; Etb receptor; Etb-svr; ETBR; ETRB; HSCR; HSCR2; WS4A
Gene Aliases: ABCDS; EDNRB; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB; HSCR; HSCR2; WS4A
UniProt ID: (Human) P24530
Entrez Gene ID: (Human) 1910