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Invitrogen
EphA5 Polyclonal Antibody
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Product Details
PA5-89694
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment).
Conjugate
Form
Liquid
Concentration
1.55 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MRGSGPRGAG RRRPPSGGGD TPITPASLAG CYSAPRRAPL WTCLLLCAAL RTLLASPSNE VNLLDSRTVM GDLGWIAFPK NGWEEIGEVD ENYAPIHTYQ VCKVMEQNQN NWLLTSWISN EGASRIFIEL; Positive Samples: U-87MG, U-251MG, Mouse brain, Rat brain; Cellular Location: Cell membrane, Cell projection, Single-pass type I membrane protein, axon, dendrite
Target Information
EPHA5 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e. g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e. g. ABL, FAK, JAK, and SRC families).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARCC2; Brain-specific kinase; CEK-7; CTPA; CTPP1; ECK; eck-like sequence 1; EHK-1; EK7; epa5; EPH homology kinase 1; EPH-like kinase 7; Ephrin A2; Ephrin A5; Ephrin type-A receptor 5; EphrinA2; EphrinA5; receptor protein-tyrosine kinase HEK7; tyrosine-protein kinase receptor EHK-1
Gene Aliases: AI854630; AW125296; BSK; CEK7; EHK-1; EHK1; EK7; Ekh1; Els1; Els1.; EPHA5; HEK7; Rek7; TYRO4
UniProt ID: (Human) P54756, (Mouse) Q60629, (Rat) P54757
Entrez Gene ID: (Human) 2044, (Mouse) 13839, (Rat) 79208
ephrin receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
ATP binding
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
growth factor receptor binding
transmembrane signal receptor
axon guidance
peptidyl-tyrosine phosphorylation
cAMP-mediated signaling
hippocampus development
positive regulation of CREB transcription factor activity
regulation of actin cytoskeleton organization
regulation of GTPase activity
ephrin receptor signaling pathway
neuron development
regulation of insulin secretion involved in cellular response to glucose stimulus
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
negative regulation of synapse assembly
dendritic spine morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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