In Western blots, approximately 5% cross-reactivity with recombinant rat (rr) EphB1, recombinant mouse (rm) EphA8, rmEphA6, rmEphB6, rmEphA3, rmEphA4, rmEphA7, rrEphA5, recombinant human EphA1, rmEphA2 and rmEphB3 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.
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Protein Aliases: CAPB; Developmentally-regulated Eph-related tyrosine kinase; DRT; EK5; ELK-related tyrosine kinase; EPH tyrosine kinase 3; EPH-like kinase 5; EPHB2; EphB2/CTF1; EphB2/CTF2; EPHB3; Ephrin B1; Ephrin B2; Ephrin B3; Ephrin B4; Ephrin type-B receptor 2; EphrinB1; EphrinB2; EphrinB3; EphrinB4; EPHT3; ERK; ETK2; HEK-6; HEK2; Hek5; MGC87492; Neural kinase; Nuk receptor tyrosine kinase; PCBC; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; Tyro5; TYRO6; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase receptor SEK-3; Tyrosine-protein kinase TYRO5
Gene Aliases: CAPB; Cek5; DRT; EK5; EPHB2; EPHT3; EPTH3; ERK; ETECK; HEK5; Nuk; PCBC; Prkm5; Qek5; Sek3; TYRO5