Invitrogen

Epiregulin Polyclonal Antibody

View all (7) Epiregulin antibodies

Questions & Answers

Questions & Answers

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Epiregulin Antibody in Immunohistochemistry (IHC) — Immunohistochemistry analysis in formalin-fixed, paraffin-embedded colon carcinoma using an EREG polyclonal antibody (Product # PA5-24727), followed by HRP-conjugated secondary antibody and DAB staining.

Epiregulin Antibody in Western Blot (WB) — Western blot analysis using an EREG polyclonal antibody (Product # PA5-24727) in HepG2 cell lysates (35 µg per lane).

Epiregulin Antibody in Flow Cytometry (Flow) — Flow cytometry analysis of HepG2 cells using an EREG polyclonal antibody (Product # PA5-24727) (right) compared to a negative control cell (left) at a dilution of 1:10-50, followed by a FITC-conjugated goat anti-rabbit antibody

Product Details

PA5-24727

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:10-1:50	-
Flow Cytometry (Flow)	1:10-1:50	-

Product Specifications
Species Reactivity	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KLH conjugated synthetic peptide between 137-165 amino acids from the C-terminal region of human EREG View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.4 mg/mL
Purification	Protein A, Antigen affinity chromatography
Storage buffer	PBS
Contains	0.09% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2542227

Target Information

EREG is a member of the epidermal growth factor family. EREG can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Epiregulin; EPR; Proepiregulin

Gene Aliases: Ep; EPR; ER; EREG

UniProt ID: (Human) O14944

Entrez Gene ID: (Human) 2069

Molecular Function: growth factor

MAPK cascade angiogenesis ovarian cumulus expansion oocyte maturation positive regulation of cytokine production female meiotic division epidermal growth factor receptor signaling pathway cell-cell signaling positive regulation of cell proliferation negative regulation of cell proliferation mRNA transcription anatomical structure morphogenesis organ morphogenesis regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway keratinocyte differentiation ovulation ERBB2 signaling pathway wound healing positive regulation of cytokine biosynthetic process positive regulation of phosphorylation luteinizing hormone signaling pathway response to peptide hormone positive regulation of GTPase activity keratinocyte proliferation positive regulation of innate immune response positive regulation of interleukin-6 biosynthetic process positive regulation of DNA replication positive regulation of epidermal growth factor-activated receptor activity positive regulation of mitotic nuclear division positive regulation of protein kinase activity negative regulation of transcription, DNA-templated phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling positive regulation of fibroblast proliferation primary follicle stage positive regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation negative regulation of smooth muscle cell differentiation positive regulation of cell division regulation of cell motility

Process(es)

protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding protein binding growth factor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity