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Invitrogen
Epo Polyclonal Antibody
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FIGURE: 1 / 4
Epo Antibody (PA5-77965) in IHC (P)
Epo Polyclonal Antibody detects EPO protein at cytoplasm in rat liver by immunohistochemical analysis. Sample: Paraffin-embedded rat liver. Epo Polyclonal Antibody (Product # PA5-77965) diluted at 1:400. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Product Details
PA5-77965
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human EPO recombinant protein.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Recombinant human EPO protein
Predicted Reactivity: Mouse (80%), Dog (81%), Rabbit (81%), Rhesus Monkey (90%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epoetin; Erythropoietin; MGC138142; unnamed protein product
Gene Aliases: DBAL; ECYT5; EP; EPO; MVCD2
UniProt ID: (Human) P01588, (Mouse) P07321, (Rat) P29676
Entrez Gene ID: (Human) 2056, (Mouse) 13856, (Rat) 24335
angiogenesis
response to hypoxia
heart morphogenesis
regulation of transcription from RNA polymerase II promoter
apoptotic process
embryo implantation
positive regulation of cell proliferation
negative regulation of calcium ion transport into cytosol
peptidyl-serine phosphorylation
erythrocyte differentiation
negative regulation of myeloid cell apoptotic process
positive regulation of tyrosine phosphorylation of Stat5 protein
hemoglobin biosynthetic process
negative regulation of apoptotic process
erythrocyte maturation
positive regulation of neuron differentiation
positive regulation of DNA replication
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
positive regulation of Ras protein signal transduction
cardiac muscle tissue morphogenesis
ventricular cardiac muscle tissue morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
visceral serous pericardium development
cellular hyperosmotic response
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
negative regulation of erythrocyte apoptotic process
negative regulation of cation channel activity
negative regulation of transcription from RNA polymerase II promoter
response to stress
acute-phase response
signal transduction
response to nutrient
blood circulation
response to salt stress
positive regulation of neuron projection development
response to lipopolysaccharide
myeloid cell apoptotic process
response to vitamin A
response to testosterone
erythropoietin-mediated signaling pathway
positive regulation of activated T cell proliferation
proteasome-mediated ubiquitin-dependent protein catabolic process
response to estrogen
response to axon injury
response to electrical stimulus
response to hyperoxia
positive regulation of ERK1 and ERK2 cascade
response to interleukin-1
response to dexamethasone
receptor signaling pathway via STAT
aging
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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