|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||Assay Dependent|
|Western Blot (WB)||Assay-Dependent|
|Immunoprecipitation (IP)||See 1 publications below|
|Western Blot (WB)||See 1 publications below|
|Tested Species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Fusion protein containing the C-terminal 150 amino acid sequence of mouse FAK expressed in bacteria.|
|Contains||0.08% sodium azide|
Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling. FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle. Tyrosine 397 is the autophosphorylation site of FAK, and involved in its initial activation. This phosphorylated site binds Src family SH2 domains and the p85 subunit of PI3-Kinase, and activates cell migration and invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 220.127.116.11; FADK 1; FAK1; Focal adhesion kinase 1; Focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; p125FAK; pp125FAK; Protein- tyrosine kinase 2; Protein-tyrosine kinase 2; PTK2
Gene Aliases: Fadk; FAK; Fak1; FRNK; Kiaa4203; mKIAA4203; p125FAK; Ptk2
UniProt ID: (Mouse) P34152
Entrez Gene ID: (Mouse) 14083
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