Immunogen sequence: AELIPDAPLSS AAYSIRSIGE RPVLKAPV
Highest antigen sequence identity to the following orthologs - mouse 83%, rat 83%.
FAM3B (family with sequence similarity 3, member B), also known as ORF9, C21orf11 or PANDER, is a 235 amino acid secreted protein that localizes to discrete vesicular and perinuclear structures. Expressed at high levels in pancreas and at lower levels in kidney, colon, testis, prostate and small intestine, FAM3B functions as an islet-specific cytokine that promotes apoptosis and may inhibit Insulin secretion from beta-cells, possibly playing a role in overall pancreatic activity. Human FAM3B shares 78% sequence identity with its mouse counterpart, suggesting a conserved role between species. Three isoforms of FAM3B, designated A, B and C, exist due to alternative splicing events.
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Protein Aliases: 21-Feb; Cytokine-like protein 2-21; D21M16SJHU19e; family with sequence similarity 3, member B; pancreatic derived factor; Pancreatic-derived factor; PANDER; Protein FAM3B
Gene Aliases: 2-21; C21orf11; C21orf76; FAM3B; ORF9; PANDER; PRED44; UNQ320/PRO365
UniProt ID: (Human) P58499
Entrez Gene ID: (Human) 54097
Molecular Function: antimicrobial response protein