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Abnova
FAM65A Polyclonal Antibody, MaxPab™
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Product Details
H00079567-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FAM65A (AAI56640.1, 1 a.a. approximately 1219 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MMSLSVRPQR RLLSARVNRS QSFAGVLGSH ERGPRSFPVF SPPGPPRKPP ALSRVSRMFS VAHPAAKVPQ PERLDLVYTA LKRGLTAYLE VHQQEQEKLQ GQIRESKRNS RLGFLYDLDK QVKSIERFLR RLEFHASKID ELYEAYCVQR RLRDGAYNMV RAYTTGSPGS REARDSLAEA TRGHREYTES MCLLESELEA QLGEFHLRMK GLAGFARLCV GDQYEICMKY GRQRWKLRGR IEGSGKQVWD SEETIFLPLL TEFLSIKVTE LKGLANHVVV GSVSCETKDL FAALPQVVAV DINDLGTIKL SLEVTWSPFD KDDQPSAASS VNKASTVTKR FSTYSQSPPD TPSLREQAFY NMLRRQEELE NGTAWSLSSE SSDDSSSPQL SGTARHSPAP RPLVQQPEPL PIQVAFRRPE TPSSGPLDEE GAVAPVLANG HAPYSRTLSH ISEASVDAAL AEASVEAVGP ESLAWGPSPP THPAPTHGEH PSPVPPALDP GHSATSSTLG TTGSVPTSTD PAPSAHLDSV HKSTDSGPSE LPGPTHTTTG STYSAITTTH SAPSPLTHTT TGSTHKPIIS TLTTTGPTLN IIGPVQTTTS PTHTMPSPTH TTASPTHTST SPTHTPTSPT HKTSMSPPTT TSPTPSGMGL VQTATSPTHP TTSPTHPTTS PILINVSPST SLELATLSSP SKHSDPTLPG TDSLPCSPPV SNSYTQADPM APRTPHPSPA HSSRKPLTSP APDPSESTVQ SLSPTPSPPT PAPQHSDLCL AMAVQTPVPT AAGGSGDRSL EEALGALMAA LDDYRGQFPE LQGLEQEVTR LESLLMQRQG LTRSRASSLS ITVEHALESF SFLNEDEDED NDVPGDRPPS SPEAGAEDSI DSPSARPLST GCPALDAALV RHLYHCSRLL LKLGTFGPLR CQEAWALERL LREARVLEAV CEFSRRWEIP ASSAQEVVQF SASRPGFLTF WDQCTERLSC FLCPVERVLL TFCNQYGARL SLRQPGLAEA VCVKFLEDAL GQKLPRRPQP GPGEQLTVFQ FWSFVETLDS PTMEAYVTET AEEVLLVRNL NSDDQAVVLK ALRLAPEGRL RRDGLRALSS LLVHGNNKVM AAVSTQLRSL SLGPTFRERA LLCFLDQLED EDVQTRVAGC LALGCIKAPE GIEPLVYLCQ TDTEAVREAA RQSLQQCGEE GQSAHRRLEE SLDALPRIFG PGSMASTAF
Target Information
Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration (PubMed:27807006). Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation (PubMed:27807006). Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation (PubMed:27807006). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: family with sequence similarity 65 member A; FLJ13725; protein FAM65A; Rho family-interacting cell polarization regulator 1; unnamed protein product
Gene Aliases: FAM65A; KIAA1930; RIPOR1
UniProt ID: (Human) Q6ZS17
Entrez Gene ID: (Human) 79567
Rho protein signal transduction
cellular response to starvation
response to wounding
positive regulation of cell migration
protein localization to Golgi apparatus
negative regulation of Rho protein signal transduction
establishment of Golgi localization
positive regulation of intracellular protein transport
cellular response to chemokine
negative regulation of Rho guanyl-nucleotide exchange factor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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