Immunogen sequence: RKEMLWGLYE SIQDYKHLCQ DLSFCQDLSS SLHSDSSYPP DAGLS
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 89%.
Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: family with sequence similarity 89, member B; Leucine repeat adapter protein 25; leucine repeat adaptor protein 25; mammary tumor virus receptor homolog 1
Gene Aliases: FAM89B; LRAP25; MTVR; MTVR1
UniProt ID: (Human) Q8N5H3
Entrez Gene ID: (Human) 23625
Molecular Function: receptor