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Bethyl Laboratories

FASN Polyclonal Antibody

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FASN Polyclonal Antibody

Product Details

IHC-00305

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

1:50-1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 2462 and 2511 of human fatty acid synthase.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Amount

25 µg

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.0 to 8.0, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Based on 100% sequence identity, this antibody is predicted to react with Rat, Goat, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Monkey, Gorilla, Chimpanzee and hirteen-lined ground squirrel

Target Information

Fatty acid synthase is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-oxoacyl-[acyl-carrier-protein] synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; Acyl-[acyl-carrier-protein] hydrolase; encodes region of fatty acid synthase activity; FAS; multifunctional protein; Enoyl-[acyl-carrier-protein] reductase; FAS; Fatty acid synthase; MGC14367; MGC15706; short chain dehydrogenase/reductase family 27X, member 1; Type I Fatty Acid Synthase

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Gene Aliases: A630082H08Rik; FAS; FASN; OA-519; SDR27X1

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UniProt ID: (Human) P49327, (Mouse) P19096

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Entrez Gene ID: (Human) 2194, (Mouse) 14104

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Function(s)
RNA binding catalytic activity fatty acid synthase activity [acyl-carrier-protein] S-acetyltransferase activity [acyl-carrier-protein] S-malonyltransferase activity 3-oxoacyl-[acyl-carrier-protein] synthase activity 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity protein binding acyl-[acyl-carrier-protein] hydrolase activity oxidoreductase activity transferase activity transferase activity, transferring acyl groups hydrolase activity lyase activity 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity phosphopantetheine binding identical protein binding cadherin binding enoyl-[acyl-carrier-protein] reductase (NADPH) activity 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity oleoyl-[acyl-carrier-protein] hydrolase activity drug binding zinc ion binding myristoyl-[acyl-carrier-protein] hydrolase activity palmitoyl-[acyl-carrier-protein] hydrolase activity hydrolase activity, acting on ester bonds protein homodimerization activity poly(A) RNA binding enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity NADPH binding
Process(es)
osteoblast differentiation epithelial cell development acetyl-CoA metabolic process lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process inflammatory response response to nutrient lipid biosynthetic process ether lipid biosynthetic process tissue development neutrophil differentiation monocyte differentiation mammary gland development response to nutrient levels modulation by host of viral process fatty-acyl-CoA biosynthetic process response to caloric restriction cellular response to interleukin-4 establishment of endothelial intestinal barrier metabolic process biosynthetic process oxidation-reduction process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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