Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4.
Predicted reactivity: Mouse (91%), Dog (96%), Pig (92%), Chimpanzee (99%), Bovine (90%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Fas-activated serine/threonine kinase; FAST kinase
Gene Aliases: FAST; FASTK
UniProt ID: (Human) Q14296
Entrez Gene ID: (Human) 10922
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