Immunogen sequence: LLDTAVELEL PGYRGPRLPR RQQVPIFPQP LITDRARCKY SHKDIVAEGL RQLLGEEKYR QDLTVPPGYC TDFLLCASSS GAVLPVRTQD PFLPYPPRSC PQGQAASSAT TRDPAQRVVL VLRERWHFCR DGRVLLGSRA LRERHLGLMG YQLLPLPFEE LESQRGLPQL KSYLRQKLQA LGLRWGPEGG; Positive Samples: NCI-H460, Mouse brain
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
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Protein Aliases: Fas-activated serine/threonine kinase; FAST kinase
Gene Aliases: 0610011K02Rik; 610011K02Rik; FAST; FASTK
UniProt ID: (Human) Q14296