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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50 - 1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50 - 1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 360-549 of human FASTK. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
3 mg/mL |
Purification |
Affinity Chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2808369 |
Immunogen sequence: LLDTAVELEL PGYRGPRLPR RQQVPIFPQP LITDRARCKY SHKDIVAEGL RQLLGEEKYR QDLTVPPGYC TDFLLCASSS GAVLPVRTQD PFLPYPPRSC PQGQAASSAT TRDPAQRVVL VLRERWHFCR DGRVLLGSRA LRERHLGLMG YQLLPLPFEE LESQRGLPQL KSYLRQKLQA LGLRWGPEGG; Positive Samples: NCI-H460, Mouse brain
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Fas-activated serine/threonine kinase; FAST kinase
Gene Aliases: 0610011K02Rik; 610011K02Rik; FAST; FASTK
UniProt ID: (Human) Q14296
Entrez Gene ID: (Human) 10922, (Mouse) 66587, (Rat) 296741
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