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FAT Polyclonal Antibody
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FIGURE: 1 / 1
FAT Antibody (BS-4278R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with FAT Polyclonal Antibody, Unconjugated (bs-4278R) at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB st... View More
Product Details
BS-4278R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FAT/CDHF7, amino acids 1401-1500.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cadherin family member 7; cadherin FAT1 isoform +12; cadherin ME5; cadherin-related family member 8; Cadherin-related tumor suppressor homolog; fat 1 cadherin; FAT tumor suppressor 1; FAT tumor suppressor homolog 1; Protein fat homolog; Protocadherin Fat 1
Gene Aliases: 2310038E12Rik; AU023433; CDHF7; CDHR8; FAT; FAT1; Fath; hFat1; ME5; mFat1
UniProt ID: (Human) Q14517
Entrez Gene ID: (Human) 2195, (Mouse) 14107, (Rat) 83720
lens development in camera-type eye
epithelial cell morphogenesis
establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
actin filament organization
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
establishment or maintenance of cell polarity
cell-cell signaling
anatomical structure morphogenesis
cell migration
camera-type eye development
cell-cell adhesion mediated by cadherin
establishment or maintenance of epithelial cell apical/basal polarity
camera-type eye morphogenesis
cell-cell adhesion
cellular response to angiotensin
positive regulation of vascular associated smooth muscle cell migration
single organismal cell-cell adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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