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Product Details
14590-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FBXO2 Fusion Protein Ag6122 (1-296 aa encoded by BC025233)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDGDGDPES VGQPEEASPE EQPEEASAEE ERPEDQQEEE AAAAAAYLDE LPEPLLLRVL AALPAAELVQ ACRLVCLRWK ELVDGAPLWL LKCQQEGLVP EGGVEEERDH WQQFYFLSKR RRNLLRNPCG EEDLEGWCDV EHGGDGWRVE ELPGDSGVEF THDESVKKYF ASSFEWCRKA QVIDLQAEGY WEELLDTTQP AIVVKDWYSG RSDAGCLYEL TVKLLSEHEN VLAEFSSGQV AVPQDSDGGG WMEISHTFTD YGPGVRFVRF EHGGQDSVYW KGWFGARVTN SSVWVEP (1-296 aa encoded by BC025233)
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: F-box gene 1; F-box only protein 2; neural F box protein NFB42; organ of Corti protein 1; prion protein ligand 4
Gene Aliases: FBG1; Fbs1; Fbs2; FBX2; FBXO2; NFB42; OCP1; Prpl4
UniProt ID: (Human) Q9UK22, (Mouse) Q80UW2
Entrez Gene ID: (Human) 26232, (Mouse) 230904, (Rat) 85273
protein polyubiquitination
cellular protein modification process
proteolysis
glycoprotein catabolic process
negative regulation of cell proliferation
protein ubiquitination
ER-associated ubiquitin-dependent protein catabolic process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
regulation of protein ubiquitination
ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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