Immunogen sequence: CLVLKVLDILQ HIQTLDPGQH GAVGYLVQHT LEHIERKKEE VGVEVKLRSD EKHRDVCYSI GLIMKHKRYG YNCVIYGWD
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 93%.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.