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Product Details
13606-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 4 publications 4 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
FBXO22 Fusion Protein Ag4485 (104-403 aa encoded by BC039024) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.17 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
This antibody recognizes isoform 1 (45 kDa) and isoform 3 (30-33 kDa).
Immunogen sequence: MADSETFIS LEECRGHKRA RKRTSMETAL ALEKLFPKQC QVLGIVTPGI VVTPMGSGSN RPQEIEIGES GFALLFPQIE GIKIQPFHFI KDPKNLTLER HQLTEVGLLD NPELRVVLVF GYNCCKVGAS NYLQQVVSTF SDMNIILAGG QVDNLSSLTS EKNPLDIDAS GVVGLSFSGH RIQSATVLLN EDVSDEKTAE AAMQRLKAAN IPEHNTIGFM FACVGRGFQY YRAKGNVEAD AFRKFFPSVP LFGFFGNGEI GCDRIVTGNF ILRKCNEVKD DDLFHSYTTI MALIHLGSSK (104-403 aa encoded by BC039024)
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Two transcript variants encoding different isoforms exist for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: F-box only protein 22; F-box protein FBX22p44; FIST domain containing 1
Gene Aliases: FBX22; FBXO22; FISTC1
UniProt ID: (Human) Q8NEZ5
Entrez Gene ID: (Human) 26263
protein polyubiquitination
cellular protein modification process
ubiquitin-dependent protein catabolic process
nucleocytoplasmic transport
cellular response to starvation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of skeletal muscle fiber development
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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