This antibody recognizes isoform 1 (45 kDa) and isoform 3 (30-33 kDa).
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Two transcript variants encoding different isoforms exist for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: F-box only protein 22; F-box protein FBX22p44; FIST domain containing 1
Gene Aliases: FBX22; FBXO22; FISTC1
UniProt ID: (Human) Q8NEZ5
Entrez Gene ID: (Human) 26263