Immunogen sequence: WQQQLNNIQI TRPAFKGLTF TDLPLCLQLN IMQRLSDGRD LVSLGQAAPD LHVLSEDRLL WKKLCQYHFS ERQIRKRLIL SDKGQLDWKK MYFKLVRCYP RKEQYGDTLQ LCKHCHILSW KGTDHPCTAN NPESCSVSLS PQDFINLFKF; Cellular Location: Cytoplasm, Nucleus
Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: atrogin 1; Atrogin-1; atrophy gene 1; F-box only protein 32; MAFbx; Muscle atrophy F-box protein
Gene Aliases: 4833442G10Rik; AI430017; ATROGIN1; Fbxo32; Gm20361; MAFbx