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Proteintech
FBXW2 Polyclonal Antibody
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Product Details
11499-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FBXW2 Fusion Protein Ag2045 (1-314 aa encoded by BC018738)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Two isoforms were produced by alternative splicing with predicted MW of 52 and 43 kDa. 11499-1-AP can recognize both forms.
Immunogen sequence: MERKDFETW LDNISVTFLS LTDLQKNETL DHLISLSGAV QLRHLSNNLE TLLKRDFLKL LPLELSFYLL KWLDPQTLLT CCLVSKQWNK VISACTEVWQ TACKNLGWQI DDSVQDALHW KKVYLKAILR MKQLEDHEAF ETSSLIGHSA RVYALYYKDG LLCTGSDDLS AKLWDVSTGQ CVYGIQTHTC AAVKFDEQKL VTGSFDNTVA CWEWSSGART QHFRGHTGAV FSVDYNDELD ILVSGSADFT VKVWALSAGT CLNTLTGHTE WVTKVVLQKC KVKSLLHSPG DYILLSADKY EIKIWPIGRE INCKC (1-314 aa encoded by BC018738)
Target Information
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: contains WD repeats; F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; F-box and WD-40 domain-containing protein 2 {ECO:0000312|EMBL:AAI66990.1}; F-box protein Fbw2; F-box/WD repeat-containing protein 2; fbxw2 {ECO:0000312|RGD:1310460}; MGC117371; Protein MD6; unnamed protein product
Gene Aliases: 2700071L08Rik; FBW2; FBXW2; FWD2; MD6
UniProt ID: (Human) Q9UKT8, (Rat) B2RZ17
Entrez Gene ID: (Human) 26190, (Rat) 311881, (Mouse) 30050
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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