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Immunogen sequence: VRNKPYDVFG CWLTETSLIS GNLHRIGDIT SCSVLWLNNA FQDVESENVN VVKRLFKIQN LNASTVRTVM VADCSRFDSP DLLLEAGDPA TSPCRIFDLG SDNEEVVAGP APAHAKEGLR HFLDRVLEGR AQPQLSERML ETKVAELLAQ GHTKPPERSA TGAKSKYLIF TTGCLTYSPH QIGIKQILPH QMTTAGPVLG EGRGSDAFFD ALDHVIDIHG HIIGMGLSPD NRYLYVNSRA WPNGAVVADP MQPPPIAEEI DLLVFDLKTM REVRRALRAH RAYTPNDECF FIFLDVSRDF VASGAEDRHG YIWDRHYNIC LARLRHEDVV NSVVFSPQEQ ELLLTASDDA TIKAWRSPRT MRVLQAPRPR PRTFFSWLAS QRR
Positive Samples: A-549; Cellular Location: Cytoplasm
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
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Protein Aliases: F-box and WD-40 domain-containing protein 5; F-box/WD repeat-containing protein 5; WD repeat-containing F-box protein FBW5
Gene Aliases: FBW5; FBXW5; PP3971
UniProt ID: (Human) Q969U6
Entrez Gene ID: (Human) 54461
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