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Proteintech
FCHSD2 Polyclonal Antibody
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Product Details
28036-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FCHSD2 fusion protein Ag27818
Conjugate
Form
Liquid
Concentration
0.85 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SRTELETCQA VQNTFQFLLE NSSKVVRDYN LQLFLQENAV FHKPQPFQFQ PCDSDTSRQL ESETGTTEEH SLNKEARKWA TRVAREHKNI VHQQRVLNDL ECHGAAVSEQ SRAELEQKID EARENIRKAE IIKLKAEARL DLLKQIGVSV DTWLKSAMNQ VMEELENERW ARPPAVTSNG TLHSLNADTE REEGEEFEDN MDVFDDSSSS
Target Information
Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Carom; F-BAR and double SH3 domains protein 2; FCH and double SH3 domains protein 2; nervous wreck homolog; NWK1; Protein nervous wreck 1; SH3 multiple domains 3; SH3 multiple domains protein 3
Gene Aliases: BC034086; FCHSD2; KIAA0769; mKIAA0769; NWK; R74866; SH3MD3
UniProt ID: (Human) O94868, (Mouse) Q3USJ8
Entrez Gene ID: (Human) 9873, (Mouse) 207278
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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