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Proteintech
FDPS Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
16129-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FDPS Fusion Protein Ag9115 (68-419 aa encoded by BC010004)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Western blot analysis using this antibody detected a major band around 41 kDa in mouse liver tissue.
Immunogen sequence: NGDQNSDVY AQEKQDFVQH FSQIVRVLTE DEMGHPEIGD AIARLKEVLE YNAIGGKYNR GLTVVVAFRE LVEPRKQDAD SLQRAWTVGW CVELLQAFFL VADDIMDSSL TRRGQICWYQ KPGVGLDAIN DANLLEACIY RLLKLYCREQ PYYLNLIELF LQSSYQTEIG QTLDLLTAPQ GNVDLVRFTE KRYKSIVKYK TAFYSFYLPI AAAMYMAGID GEKEHANAKK ILLEMGEFFQ IQDDYLDLFG DPSVTGKIGT DIQDNKCSWL VVQCLQRATP EQYQILKENY GQKEAEKVAR VKALYEELDL PAVFLQYEED SYSHIMALIE QYAAPLPPAV FLGLARKIYK RRK (68-419 aa encoded by BC010004)
Target Information
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (2E,6E)-farnesyl diphosphate synthase; cholesterol-regulated 39 kDa protein; cholesterol-regulated protein CR39; CR 39; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase); farnesyl diphosphate synthetase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase (EC 2.5.1.1); farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; farnesyl-diphosphate synthase; Fdps; FPP synthase; FPP synthetase; FPS; geranyltranstransferase; KIAA1293; testis-specific farnesyl pyrophosphate synthetase; unnamed protein product
Gene Aliases: 6030492I17Rik; Ac2-125; Fdpsl1; FPPS; FPS; mKIAA1293; POROK9
UniProt ID: (Human) P14324, (Mouse) Q920E5, (Rat) P05369
Entrez Gene ID: (Human) 2224, (Mouse) 110196, (Rat) 83791
cholesterol biosynthetic process
isoprenoid biosynthetic process
farnesyl diphosphate biosynthetic process, mevalonate pathway
geranyl diphosphate biosynthetic process
geranylgeranyl diphosphate biosynthetic process
zymosterol biosynthetic process
farnesyl diphosphate biosynthetic process
positive regulation of cholesterol biosynthetic process
positive regulation of cell growth involved in cardiac muscle cell development
spermatogenesis
male gonad development
response to xenobiotic stimulus
response to testosterone
response to peptide hormone
response to cholesterol
cellular response to fatty acid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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