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FEM 1B Polyclonal Antibody
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Product Details
BS-7113R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FEM 1B, amino acids 531-627.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp451E0710; F1A-alpha; FEM-1-like death receptor binding protein; Fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; FEM1-beta; FEM1b; feminization 1 homolog b; FIAA; KIAA0396; mt-Fem; Protein fem-1 homolog B; similar to Caenorhabditis elegans FEM-1; unnamed protein product
Gene Aliases: F1A-ALPHA; F1AA; FEM1-beta; FEM1B; KIAA0396; mKIAA0396
UniProt ID: (Human) Q9UK73, (Mouse) Q9Z2G0, (Rat) P0C6P7
Entrez Gene ID: (Human) 10116, (Mouse) 14155, (Rat) 315745
epithelial cell maturation
apoptotic process
protein ubiquitination
regulation of ubiquitin-protein transferase activity
branching involved in prostate gland morphogenesis
epithelial cell maturation involved in prostate gland development
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of DNA damage checkpoint
proteasome-mediated ubiquitin-dependent protein catabolic process
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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