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Invitrogen

FER Polyclonal Antibody

View all (13) FER antibodies

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FER Polyclonal Antibody

Product Details

PA5-121237

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human FER (NP_005237.2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.73 mg/mL

Amount

73 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914809

Product Specific Information

Positive test controls include: HeLa, HT-1080, SW480, LO2, NIH/3T3, Mouse liver, Mouse heart, Rat brain. The target is usually found in the following locations: Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Membrane, Nucleus, Peripheral membrane protein, cell cortex, cytoskeleton.

Immunogen sequence: YDITLPLLLD SLQKMQEEMI KALKGIFDEY SQITSLVTEE IVNVHKEIQM SVEQIDPSTE YNNFIDVHRT TAAKEQEIEF DTSLLEENEN LQANEIMWNN LTAESLQVML KTLAEELMQT QQMLLNKEEA VLELEKRIEE SSETCEKKSD IVLLLSQKQA LEELKQSVQQ LRCTEAKFSA QKELLEQKVQ ENDGKEPPPV VNYEEDARSV TSMERKERLS KFESIRHSIA GIIRSPKSAL GSSALSDMIS I

Target Information

FER is a member of the FPS/FES family of non-receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. FER is found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes. The group IV cytoplasmic protein-tyrosine kinase Fer has been linked to cellular signaling responses to many different stimuli, including growth factors and cytokines. Data suggest a biological role for Fer in regulation of leukocyte recruitment during the innate immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-FER; EC 2.7.10.2; feline encephalitis virus-related kinase FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fps/fes related) tyrosine kinase; fujinami poultry sarcoma/Feline sarcoma-related protein Fer; iFer; p47; p94-FER; phosphoprotein NCP94; protein phosphatase 1, regulatory subunit 74; proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase FER; testis-specific tyrosine kinase; tyrosine kinase (FER); tyrosine kinase (ferT); tyrosine kinase 3; tyrosine protein kinase FLK; unnamed protein product

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Gene Aliases: C330004K01Rik; Fert; Fert2; Flk; Flk_retired; p94-Fer; PPP1R74; TYK3

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UniProt ID: (Human) P16591, (Mouse) P70451, (Rat) P09760

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Entrez Gene ID: (Human) 2241, (Mouse) 14158, (Rat) 301737

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Function(s)
protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity epidermal growth factor receptor binding protein binding ATP binding protein phosphatase 1 binding lipid binding
Process(es)
microtubule cytoskeleton organization regulation of protein phosphorylation protein phosphorylation chemotaxis cell adhesion tyrosine phosphorylation of STAT protein germ cell development positive regulation of cell proliferation insulin receptor signaling pathway male gonad development regulation of lamellipodium assembly regulation of fibroblast migration peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway actin cytoskeleton organization positive regulation of cell migration positive regulation of actin filament polymerization positive regulation of protein polymerization response to lipopolysaccharide negative regulation of mast cell activation involved in immune response adherens junction assembly substrate adhesion-dependent cell spreading cellular response to reactive oxygen species extracellular matrix-cell signaling intracellular signal transduction cellular response to macrophage colony-stimulating factor stimulus response to platelet-derived growth factor Fc-epsilon receptor signaling pathway Kit signaling pathway regulation of epidermal growth factor receptor signaling pathway cell-cell adhesion mediated by cadherin protein autophosphorylation platelet-derived growth factor receptor signaling pathway diapedesis positive regulation of cytoskeleton organization Sertoli cell development interleukin-6-mediated signaling pathway seminiferous tubule development regulation of plasma membrane bounded cell projection organization adherens junction disassembly positive regulation of supramolecular fiber organization signal transduction positive regulation of protein kinase B signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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