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Invitrogen
FER Polyclonal Antibody
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Product Details
PA5-82309
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FER. Recombinant protein control fragment (Product #RP-89792).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QVMLKTLAEE LMQTQQMLLN KEEAVLELEK RIEESSETCE KKSDIVLLLS QKQALEELKQ SVQQLRCTEA KFSAQKELLE QKVQENDGKE PPPVVNYEED ARSVTSMERK ERLSKFESIR HSIAGIIRSP KS
Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 94%.
Target Information
FER is a member of the FPS/FES family of non-receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. FER is found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes. The group IV cytoplasmic protein-tyrosine kinase Fer has been linked to cellular signaling responses to many different stimuli, including growth factors and cytokines. Data suggest a biological role for Fer in regulation of leukocyte recruitment during the innate immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.10.2; Feline encephalitis virus-related kinase FER; fer (fps/fes related) tyrosine kinase; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; p47; p94-Fer; phosphoprotein NCP94; protein phosphatase 1, regulatory subunit 74; Proto-oncogene c-Fer; Tyrosine kinase 3; Tyrosine-protein kinase Fer
Gene Aliases: FER; p94-Fer; PPP1R74; TYK3
UniProt ID: (Human) P16591
Entrez Gene ID: (Human) 2241
microtubule cytoskeleton organization
mitotic cell cycle
regulation of protein phosphorylation
protein phosphorylation
chemotaxis
cell adhesion
cell proliferation
positive regulation of cell proliferation
regulation of lamellipodium assembly
regulation of fibroblast migration
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
cell differentiation
positive regulation of cell migration
positive regulation of actin filament polymerization
actin cytoskeleton reorganization
response to lipopolysaccharide
cellular response to insulin stimulus
negative regulation of mast cell activation involved in immune response
substrate adhesion-dependent cell spreading
cellular response to reactive oxygen species
extracellular matrix-cell signaling
intracellular signal transduction
cellular response to macrophage colony-stimulating factor stimulus
response to platelet-derived growth factor
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
Kit signaling pathway
regulation of epidermal growth factor receptor signaling pathway
tyrosine phosphorylation of Stat3 protein
regulation of mast cell degranulation
cell-cell adhesion mediated by cadherin
innate immune response
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
diapedesis
positive regulation of NF-kappaB transcription factor activity
interleukin-6-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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