FGFBP1 encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4.
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Protein Aliases: 17 kDa HBGF-binding protein; 17 kDa heparin-binding growth factor-binding protein; FGF-binding protein 1; FGF-BP; Fibroblast growth factor-binding protein 1; heparin-binding growth factor binding protein
Gene Aliases: FGF-BP; FGF-BP1; FGFBP; FGFBP-1; FGFBP1; HBP17
UniProt ID: (Human) Q14512
Entrez Gene ID: (Human) 9982