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          • Primary Antibodies ›
          • FGFR2 Antibodies

          Bioss

          FGFR2 Polyclonal Antibody

          View all (70) FGFR2 antibodies

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          Cite FGFR2 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (2)
          FGFR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          FGFR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          FGFR2 Antibody (BS-0675R) in IHC (P)

          Paraformaldehyde-fixed, paraffin embedded human skin; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with FGFR2 Polyclonal Antibody, Unconjugated (bs-0675R) at 1:400 overnight at 4°C, followed by a conjugated secondary for 20 minutes and DAB... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          FGFR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          FGFR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          FGFR2 Polyclonal Antibody

          Product Details

          BS-0675R

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (Paraffin) (IHC (P))

          1:400
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -

          Flow Cytometry (Flow)

          1:100
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human FGFR2, amino acids 21-120.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          FGFR2 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: bacteria-expressed kinase; BEK fibroblast growth factor receptor; CD332; FGF Receptor; FGF Receptor 2; FGF-10; FGFR; FGFR-2; FGFR2; Fibroblast growth factor receptor 2; K-sam; Keratinocyte growth factor receptor; KGFR; protein tyrosine kinase, receptor like 14; Soluble KGFR; transmembrane protein tyrosine kinase; unnamed protein product

          View more View less

          Gene Aliases: AU043015; AW556123; BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; Fgfr-2; Fgfr-7; FGFR2; Fgfr7; JWS; K-SAM; KGFR; KGFRTr; KSAM; svs; TK14; TK25

          View more View less

          UniProt ID: (Human) P21802, (Mouse) P21803

          View more View less

          Entrez Gene ID: (Human) 2263, (Mouse) 14183, (Rat) 25022

          View more View less

          Function(s)
          nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding heparin binding kinase activity transferase activity fibroblast growth factor binding identical protein binding protein homodimerization activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter angiogenesis ureteric bud development in utero embryonic development epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation outflow tract septum morphogenesis membranous septum morphogenesis endochondral bone growth apoptotic process cell-cell signaling axonogenesis positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway regulation of smoothened signaling pathway post-embryonic development embryonic pattern specification organ morphogenesis positive regulation of phospholipase activity negative regulation of keratinocyte proliferation morphogenesis of embryonic epithelium peptidyl-tyrosine phosphorylation orbitofrontal cortex development ventricular zone neuroblast division pyramidal neuron development gland morphogenesis positive regulation of Wnt signaling pathway bone mineralization lung development epithelial cell differentiation midbrain development otic vesicle formation hair follicle morphogenesis response to lipopolysaccharide lacrimal gland development regulation of osteoblast proliferation organ growth fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow fibroblast growth factor receptor signaling pathway involved in hemopoiesis fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development inner ear morphogenesis odontogenesis chordate embryonic development positive regulation of MAPK cascade cellular response to fibroblast growth factor stimulus cell fate commitment response to ethanol regulation of cell differentiation regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation lung alveolus development mesodermal cell differentiation embryonic digestive tract morphogenesis embryonic organ morphogenesis digestive tract development embryonic organ development reproductive structure development embryonic cranial skeleton morphogenesis skeletal system morphogenesis epidermis morphogenesis branching morphogenesis of a nerve mesenchymal cell differentiation positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation regulation of smooth muscle cell differentiation positive regulation of cell division ventricular cardiac muscle tissue morphogenesis positive regulation of cardiac muscle cell proliferation limb bud formation bone development bone morphogenesis branching involved in prostate gland morphogenesis branching involved in salivary gland morphogenesis bud elongation involved in lung branching lung lobe morphogenesis lung-associated mesenchyme development positive regulation of epithelial cell proliferation involved in lung morphogenesis prostate gland morphogenesis prostate epithelial cord elongation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis squamous basal epithelial stem cell differentiation involved in prostate gland acinus development fibroblast growth factor receptor signaling pathway involved in mammary gland specification lateral sprouting from an epithelium mammary gland bud formation epithelial cell proliferation involved in salivary gland morphogenesis branch elongation involved in salivary gland morphogenesis branching involved in labyrinthine layer morphogenesis regulation of morphogenesis of a branching structure mesenchymal cell differentiation involved in lung development mesenchymal cell proliferation involved in lung development regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to retinoic acid cellular response to hypoxia cellular response to transforming growth factor beta stimulus positive regulation of canonical Wnt signaling pathway positive regulation of vascular smooth muscle cell proliferation cranial skeletal system development protein phosphorylation neuromuscular junction development negative regulation of cell proliferation regulation of cell fate commitment phosphorylation multicellular organism growth regulation of multicellular organism growth regulation of fibroblast growth factor receptor signaling pathway regulation of cell proliferation negative regulation of mitotic nuclear division synaptic vesicle transport positive regulation of smooth muscle cell proliferation epithelial cell proliferation regulation of epithelial cell proliferation coronal suture morphogenesis epithelial tube branching involved in lung morphogenesis regulation of branching involved in prostate gland morphogenesis vasculogenesis involved in coronary vascular morphogenesis endodermal digestive tract morphogenesis lens fiber cell development
          It has to be done as per old AB suggested Products section.

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          Host server : magellan-search-blue-67655d8755-b2k9d:80/100.66.79.173:80.
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