PA1-24764 detects overexpressed FGFR2 from transfected human samples. This antibody shows no cross reactivity with FGFR1 or FGFR3.
PA1-24764 has been successfully used in immunoprecipitation, immunohistochemistry (paraffin), and Western blot procedures. The molecular weight is 110 kDa.
The PA1-24764 immunogen is a synthetic peptide, conjugated to KLH by a Glutaraldehyde linker, corresponding to residues A(362) P G R E K E I T A S P D K(374) of human FGFR2.
Avoid freeze/thaw cycles
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
FGFR2 is a member of the fibroblast growth factor receptor family. It is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a central role in the regulation of cell proliferation, differentiation, migration, apoptosis, and embryonic development. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: bacteria-expressed kinase; BEK; BEK fibroblast growth factor receptor; BFR-1; CD332; CEK3; CFD1; ECT1; FGF Receptor 2; FGFR-2; Fibroblast Growth Factor Receptor 2; JWS; K-SAM; Keratinocyte growth factor receptor; KGFR; protein tyrosine kinase, receptor like 14; TK14; TK25
Gene Aliases: BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; FGFR2; JWS; K-SAM; KGFR; KSAM; TK14; TK25
UniProt ID: (Human) P21802
Entrez Gene ID: (Human) 2263