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Invitrogen
FGL2 Polyclonal Antibody
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FIGURE: 1 / 6
FGL2 Antibody (PA5-71472) in WB
Western blot analysis of FGL2 in various lysates. Samples were incubated with FGL2 polyclonal antibody (Product # PA5-71472) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Lane 1: Hela whole cell lysate; Lane 2: HL-60 whole cell lysate; Lane 3: KG-1 whole cell lysate. Predicted band size: 50 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-71472
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 338-367 amino acids from the C-terminal region of human FGL2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Fibrinogen-like protein 2 (Fgl2), also known as fibroleukin, is secreted by T cells and is involved in diseases in which thrombosis plays a pivotal role, such as virus-induced fulminant hepatitis, fetal loss syndrome and xenograft rejection. Constitutively expressed in cytotoxic T cells, Fgl2 exerts immunosuppressive effects on both T cell proliferation and dendritic cell maturation. Fgl2 is a serine protease and directly cleaves prothrombin to thrombin. Fgl2 functions in the pathogenesis of diseases including viral-induced hepatitis and Th1 cytokine-induced fetal loss syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: associated with MHV-3 induced prothrombinase activity; Cytotoxic T-lymphocyte-specific protein; Fibrinogen-like protein 2; Fibroleukin; Prothrombinase; pT49; unnamed protein product
Gene Aliases: AI385601; FGL2; Fiblp; musfiblp; pT49; T49
UniProt ID: (Human) Q14314, (Mouse) P12804
Entrez Gene ID: (Human) 10875, (Mouse) 14190
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
negative regulation of dendritic cell antigen processing and presentation
negative regulation of macrophage antigen processing and presentation
negative regulation of memory T cell differentiation
negative regulation of defense response to virus
cytolysis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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