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Product Details
PA5-35962
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:3,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant fragment corresponding to a region within amino acids 1494 and 1594 of RB1CC1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7, with 20% glycerol |
Contains |
0.025% ProClin 300 |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2553272 |
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, human RB1CC1-transfected 293T.
Predicted reactivity: Mouse (100%), Rat (98%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 200 kDa FAK family kinase-interacting protein; FAK family kinase-interacting protein of 200 kDa; FIP200; phosphatase 1, regulatory subunit 131; RB1-inducible coiled-coil 1; RB1-inducible coiled-coil protein 1
Gene Aliases: ATG17; CC1; FIP200; KIAA0203; PPP1R131; RB1CC1; RBICC
UniProt ID: (Human) Q8TDY2
Entrez Gene ID: (Human) 9821
Molecular Function:
scaffold/adaptor protein
autophagosome assembly
liver development
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
autophagy
cell cycle
JNK cascade
heart development
regulation of autophagy
macroautophagy
positive regulation of cell size
negative regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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