Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MPVFSRAPA RRHSRVRPKV TVLNYASPIT AVSRPLNEMV LTPLTEQEGE AYLEKCGSVR RHTVANAHSD IQLLAMATMM HSGLGEEASS ENKCLLLPPS FPPPHRQCSS EPNITDNPDG LEEGARGSQE GSELNCASLS (1-139 aa encoded by BC008922)
Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Proline-rich protein 5-like; Protein observed with Rictor-2; Protor-2
Gene Aliases: PROTOR2; PRR5L
UniProt ID: (Human) Q6MZQ0
Entrez Gene ID: (Human) 79899
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