Invitrogen

FOXA1 Polyclonal Antibody

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FOXA1 Polyclonal Antibody

Product Details

PA5-90342

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 263-472 of human FOXA1 (NP_0044872)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.84 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806034

Product Specific Information

Immunogen sequence: QKRFKCEKQP GAGGGGGSGS GGSGAKGGPE SRKDPSGASN PSADSPLHRG VHGKTGQLEG APAPGPAASP QTLDHSGATA TGGASELKTP ASSTAPPISS GPGALASVPA SHPAHGLAPH ESQLHLKGDP HYSFNHPFSI NNLMSSSEQQ HKLDFKAYEQ ALQYSPYGST LPASLPLGSA SVTTRSPIEP SALEPAYYQG VYSRPVLNTS; Positive Samples: A-549, MCF7, LO2, HeLa, Mouse lung; Cellular Location: Nucleus

Target Information

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ci-fkh; fkd7; fkh; fork head domain; Forkhead box protein A1; forkhead-7; FoxA4a; hepatocyte nuclear factor 3 alpha (winged helix transcription factor); hepatocyte nuclear factor 3, alpha; Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; HNF3-alpha; HNF3alpha; MGC33105; MGC52590; MGC75967; pintallavis; TCF-3A; tFoxA1; Transcription factor 3A; xfkh1; xfkh2

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Gene Aliases: FOXA1; Hnf-3a; HNF3A; Tcf-3a; TCF3A

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UniProt ID: (Human) P55317, (Mouse) P35582, (Rat) P23512

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Entrez Gene ID: (Human) 3169, (Mouse) 15375, (Rat) 25098

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding protein domain specific binding sequence-specific DNA binding transcription regulatory region DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding double-stranded DNA binding winged helix/forkhead transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin remodeling transcription from RNA polymerase II promoter Notch signaling pathway negative regulation of epithelial to mesenchymal transition covalent chromatin modification dorsal/ventral neural tube patterning response to estradiol positive regulation of intracellular estrogen receptor signaling pathway hormone metabolic process glucose homeostasis positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter anatomical structure formation involved in morphogenesis neuron fate specification positive regulation of sequence-specific DNA binding transcription factor activity epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development epithelial-mesenchymal signaling involved in prostate gland development prostate gland epithelium morphogenesis prostate gland stromal morphogenesis epithelial cell maturation involved in prostate gland development alveolar secondary septum development dopaminergic neuron differentiation respiratory basal cell differentiation positive regulation of cell-cell adhesion mediated by cadherin transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development regulation of gene expression chromatin modification lung development tube morphogenesis regulation of cell cycle connective tissue development
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