This antibody is predicted to react with rat and zebrafish based on sequence homology.
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.
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Protein Aliases: forkhead box A2; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3 beta (winged helix transcription factor); hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; hepatocyte nuclear factor-3beta; HNF-3-beta; HNF-3B; HNF3B, MGC19807, TCF3B, HNF-3-beta; TCF-3B; Transcription factor 3B; transcription factor Foxa2
Gene Aliases: FOXA2; Hnf-3b; HNF-3BETA; HNF3-beta; HNF3B; HNF3beta; Tcf-3b; TCF3B