This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.
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Protein Aliases: ARA; congenital hydrocephalus; FKHL7; forkhead (Drosophila)-like 7; forkhead box C1; forkhead box C1 protein; Forkhead box C1-A; Forkhead box C1-B; Forkhead box protein C1; Forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FOXC1; FREAC-3; FREAC3; IGDA; IHG1; IRID1; iridogoniodysgenesis type 1; Mesoderm/mesenchyme forkhead 1; MF-1; myeloid factor-delta; RIEG3; Transcription factor FKH-1
Gene Aliases: ARA; ch; fkh-1; Fkh1; FKHL7; FOXC1; foxc1.1; foxc1.2; foxc1a; foxc1b; FREAC-3; FREAC3; frkhda; id:ibd5079; IGDA; IHG1; IRID1; Mf1; Mf4; RIEG3