A suggested positive control is human liver tissue lysate.
PA5-34474 can be used with blocking peptide PEP-1516.
FOXH1 is a member of the Forkhead-box (FOX) family of transcription factors and is the human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 plays an important role in mediating TGF-beta/activin signals through its interaction with the SMAD2-SMAD4 complex. It is expressed primarily during early development and localizes in the cytoplasm until it forms a complex with the SMAD proteins at which time it translocates to the nucleus to positively or negatively affect gene expression.
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Protein Aliases: Fast-1; Fast-2; FAST1 transcription factor; forkhead activin signal transducer; Forkhead activin signal transducer 1; Forkhead activin signal transducer 2; forkhead activin signal transducer-1; forkhead activin signal transducer-2; Forkhead box H1; Forkhead box protein H1; FOXH1; hFAST-1; TGF-beta/activin signal transducer
Gene Aliases: FAST-1; fast-2; FAST1; FAST2; FOXH1