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Product Details
PA5-21618
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region within amino acids 585 and 648 of FOXN1 (Uniprot ID#O15353)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_11152532
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, A549, H1299, HCT116.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FOXN1 is a 648 amino acid protein belonging to the winged helix/forkhead family It contains 1 fork-head DNA-binding domain and is a transcriptional regulator involved in development. FOXN1 is involved in directing lineage choices of multi-potential progenitor epithelial cells and controls important regulating genes of lympho-epithelial interactions. It modulates keratinocyte differentiation in hair follicles and nail apparatus and its defects lead to T-cell immunodeficiency congenital alopecia, nail dystrophy, macroscopic nudity and an inborn dysgenesis of the thymus.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Forkhead box protein N1; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/forkhead homolog 11; JTK1; Rowett nude; winged helix nude; winged-helix nude; Winged-helix transcription factor nude
Gene Aliases: D11Bhm185e; Fkh19; FKHL20; FOXN1; HFH-11; Hfh11; nu; nude; Rnu; RONU; WHN
UniProt ID: (Human) O15353, (Mouse) Q61575
Entrez Gene ID: (Human) 8456, (Rat) 287469, (Mouse) 15218
hair follicle development
lymphocyte homeostasis
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
cell proliferation
epidermis development
regulation of gene expression
keratinocyte differentiation
regulation of T cell differentiation in thymus
nail development
thymus development
epithelial cell proliferation
T cell lineage commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
hemopoiesis
cell differentiation
T cell homeostasis
blood vessel morphogenesis
positive regulation of hair follicle development
lymphoid lineage cell migration into thymus
thymus epithelium morphogenesis
regulation of positive thymic T cell selection
defense response
organ morphogenesis
positive regulation of epithelial cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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