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          • Primary Antibodies ›
          • FOXO1/FOXO3/FOXO4 Antibodies

          Bioss

          FOXO1/3/4 Polyclonal Antibody

          View all (8) FOXO1/FOXO3/FOXO4 antibodies

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          Cite FOXO1/3/4 Polyclonal Antibody

          Additional Information:
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          Product Details

          BS-7068R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          Assay-dependent
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human FOXO1 + FOXO3 + FOXO4.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: AF6q21 protein; AFX; AFX1; Afxh; Fork head domain transcription factor AFX1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box O3A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O3; Forkhead box protein O4; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma-like 1; forkhead protein; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOX04b; FOXO3A-; MGC120490; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; unnamed protein product

          View more View less

          Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; AFX; AFX1; Afxh; AI876417; C76856; FKH1; FKHR; Fkhr1; Fkhr2; Fkhr3; FKHRL1; FKHRL1P2; FOXO1; FOXO1A; FOXO2; FOXO3; FOXO3A; FOXO4; MLLT7; RGD1561201

          View more View less

          UniProt ID: (Human) Q12778, (Human) O43524, (Human) P98177, (Rat) G3V7R4, (Mouse) Q9R1E0, (Mouse) Q9WVH4, (Mouse) Q9WVH3

          View more View less

          Entrez Gene ID: (Human) 2308, (Human) 2309, (Human) 4303, (Rat) 84482, (Mouse) 56458, (Mouse) 56484, (Rat) 294515, (Rat) 302415, (Mouse) 54601

          View more View less

          Function(s)
          RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding chromatin DNA binding ubiquitin protein ligase binding sequence-specific DNA binding protein phosphatase 2A binding promoter-specific chromatin binding transcription regulatory region sequence-specific DNA binding transcription cofactor binding protein kinase binding mitochondrial RNA polymerase binding promoter specificity activity sequence-specific double-stranded DNA binding enzyme binding identical protein binding DNA-binding transcription factor binding transcription factor activity, transcription factor binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor binding core promoter binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of translation apoptotic process anatomical structure morphogenesis cell differentiation DNA damage response, signal transduction by p53 class mediator cellular response to oxidative stress glucose homeostasis positive regulation of neuron apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process cell cycle arrest mitotic G2 DNA damage checkpoint negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of angiogenesis stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition blood vessel development autophagy cellular response to DNA damage stimulus cellular response to starvation positive regulation of autophagy cellular response to insulin stimulus negative regulation of stress-activated MAPK cascade regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter regulation of cell proliferation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of protein catabolic process cellular response to hyperoxia cellular response to nitric oxide regulation of nucleic acid-templated transcription response to oxidative stress muscle organ development positive regulation of smooth muscle cell migration response to nutrient levels proteasome-mediated ubiquitin-dependent protein catabolic process protein K48-linked ubiquitination response to water-immersion restraint stress cell cycle multicellular organism development temperature homeostasis cellular glucose homeostasis gluconeogenesis regulation of gluconeogenesis protein acetylation gene expression response to insulin positive regulation of smooth muscle cell apoptotic process fat cell differentiation negative regulation of transcription, DNA-templated negative regulation of insulin secretion canonical Wnt signaling pathway regulation of transcription initiation from RNA polymerase II promoter cellular response to cold response to fatty acid energy homeostasis negative regulation of cardiac muscle hypertrophy in response to stress transcription from mitochondrial promoter response to xenobiotic stimulus positive regulation of muscle atrophy negative regulation of cell migration tumor necrosis factor-mediated signaling pathway cellular response to glucose starvation response to starvation positive regulation of regulatory T cell differentiation negative regulation of neuron differentiation brain morphogenesis cellular response to glucose stimulus cellular response to corticosterone stimulus cellular response to hypoxia response to dexamethasone positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of reactive oxygen species biosynthetic process cellular response to beta-amyloid cellular response to nerve growth factor stimulus positive regulation of endothelial cell apoptotic process
          It has to be done as per old AB suggested Products section.

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