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FOXP1 Antibody (PA5-119678) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human tonsil tissue using FOXP1 Polyclonal Antibody (Product # PA5-119678). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the FOXP1 antibody at a dilution of... View More
Product Details
PA5-119678
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within C-terminal of human FoxP1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913251
Product Specific Information
Positive Control: HepG2, rat spleen tissue, rat brain tissue, human colon tissue, human breast tissue, human tonsil tissue, MCF-7.
Subcellular Location: Nucleus.
Target Information
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1; Forkhead box protein P1 (FOXP1); Glutamine rich factor 1; glutamine-rich factor 1; Mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551
Gene Aliases: 12CC4; FOXP1; hFKH1B; HSPC215; MFH; QRF1
UniProt ID: (Human) Q9H334, (Rat) Q498D1
Entrez Gene ID: (Human) 27086, (Rat) 297480
RNA polymerase II transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
protein self-association
metal ion binding
androgen receptor binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein homodimerization activity
protein heterodimerization activity
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
positive regulation of mesenchymal cell proliferation
pre-B cell differentiation
positive regulation of immunoglobulin production
negative regulation of B cell apoptotic process
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
heart development
skeletal muscle tissue development
motor neuron axon guidance
positive regulation of endothelial cell migration
ventral spinal cord development
osteoclast differentiation
lung development
response to lipopolysaccharide
regulation of tumor necrosis factor production
immunoglobulin V(D)J recombination
chemokine (C-C motif) ligand 2 secretion
osteoclast development
macrophage activation
monocyte activation
endothelial cell activation
sarcomere organization
regulation of monocyte differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
smooth muscle tissue development
positive regulation of epithelial cell proliferation
regulation of interleukin-1 beta secretion
regulation of inflammatory response
cardiac muscle cell differentiation
regulation of cardiac muscle cell proliferation
negative regulation of androgen receptor signaling pathway
lung secretory cell differentiation
T follicular helper cell differentiation
cardiovascular system development
interleukin-21 secretion
regulation of defense response to bacterium
regulation of lung goblet cell differentiation
negative regulation of lung goblet cell differentiation
regulation of macrophage colony-stimulating factor production
regulation of endothelial tube morphogenesis
positive regulation of cardiac muscle cell differentiation
regulation of interleukin-12 secretion
transcription, DNA-templated
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