PA5-27914 targets Folylpolyglutamate synthase in WB applications and shows reactivity with Human samples.
The PA5-27914 immunogen is recombinant fragment corresponding to a region within amino acids 222 and 488 of Human Folylpolyglutamate synthase.
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This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
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Protein Aliases: Folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase; Folylpolyglutamate synthase, mitochondrial; FPGS; mitochondrial; Tetrahydrofolate synthase; Tetrahydrofolylpolyglutamate synthase
Gene Aliases: FPGS
UniProt ID: (Human) Q05932
Entrez Gene ID: (Human) 2356
Molecular Function: ligase