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Product Details
30107-100UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
NFPR1
Immunogen
His-tagged recombinant FPR1 (human neutrophil N-formyl peptide receptor 1) expressed in and purified from Sf9 cells.
Conjugate
Form
Liquid
Concentration
0.5-1.0 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Formyl peptide receptors (FPR) are G protein-coupled receptors that are activated by different agonists included N- formylated peptides originating from bacteria and mitochondria. In humans, the FPR family includes the high affinity FPR1, the low affinity FPR2/ALX (previously known as FPRL1 or ALX) and FPR3. Human FPR1 is important for phagocyte chemotaxis, superoxide production, and degranulation, and helps direct phagocytes to sites of infection. Functional FPR1expression has been demonstrated on fibroblasts, bone marrow mesenchymal stem cells, A549 lung cells, HEP-G2 hepatoma cells, and on several types of epithelial cells. FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include Diamond-Blackfan Anemia 2 and Prion Disease. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fMet-Leu-Phe receptor; fMLP receptor; FMLP-R-I; FMLP-related receptor I; Formyl peptide receptor-like 1; FPR; HM63; Lipoxin A4 receptor; lipoxin A4 receptor (formyl peptide receptor related); LXA4 receptor; N-formyl peptide receptor; N-formyl peptide receptor 2; N-formylpeptide chemoattractant receptor; RFP
Gene Aliases: ALXR; FMLP; FMLP-R-II; FMLPX; FPR; FPR1; FPR2; FPR2A; FPRH1; FPRH2; FPRL1; HM63; LXA4R
UniProt ID: (Human) P21462, (Human) P25090
Entrez Gene ID: (Human) 2357, (Human) 2358
activation of MAPK activity
movement of cell or subcellular component
chemotaxis
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
nitric oxide mediated signal transduction
inflammatory response
cell adhesion
Performance Guarantee
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