|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide, conjugated to KLH, corresponding to residues 487-505 of human FRS2alpha.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4, with 1% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunoprecipitation (IP)||10 - 20 µg per 3 mg RIPA|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24685 detects FRS2 from human, mouse, and rat samples.
PA1-24685 has been successfully used in Western blot and immunoprecipitation procedures. PA1-24685 detects a band of ~92 and 95 kDa. Positive control of rat PC-12 and human HepG2 cell lysates suggested.
The PA1-24685 immunogen is a synthetic peptide, conjugated to KLH, corresponding to residues 487-505 of human FRS2alpha.
Store at 4°C short term. For extended storage, aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.