PA1-24685 detects a band of ~92 and 95 kDa. Positive control of rat PC-12 and human HepG2 cell lysates suggested.
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. [UniProt]
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Protein Aliases: FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast growth factor receptor substrate 2; FRS2-alpha; SNT-1; SNT2; Suc1-associated neurotrophic factor target 1
Gene Aliases: 4732458E18; C330018A15Rik; FRS1A; FRS2; FRS2A; FRS2alpha; SNT; SNT-1; SNT1