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Proteintech
FRS3 Polyclonal Antibody
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Product Details
12249-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FRS3 Fusion Protein Ag2896 (1-303 aa encoded by BC010611)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGSCCSCLN RDSVPDNHPT KFKVTNVDDE GVELGSGVME LTQSELVLHL HRREAVRWPY LCLRRYGYDS NLFSFESGRR CQTGQGIFAF KCSRAEEIFN LLQDLMQCNS INVMEEPVII TRNSHPAELD LPRAPQPPNA LGYTVSSFSN GCPGEGPRFS APRRLSTSSL RHPSLGEEST HALIAPDEQS HTYVNTPASE DDHRRGRHCL QPLPEGQAPF LPQARGPDQR DPQVFLQPGQ VKFVLGPTPA RRHMVKCQGL CPSLHDPPHH NNNNEAPSEC PAQPKCTYEN VTGGLWRGAG WRLS (1-303 aa encoded by BC010611)
Target Information
FRS3 (fibroblast growth factor receptor substrate 3), also known as FRS2B (FRS2-beta), is a 492 amino acid lipid-anchor adapter protein that contains one IRS-type PTB domain. Colocalizing to neural tissues with Tuj1, FRS3 functions as a feedback inhibitor of EGFR family members by preventing heterodimer formation between EGFR and ErbB2, thereby acting as a potential tumor suppressor. FRS3 is phosphorylated upon stimulation by FGF-2 or NGF and, acting as an adapter protein, links c-Fgr and NGF receptors to downstream signaling pathways. Interfering with the phosphorylation and nuclear translocation of ERK-2, FRS3 down-regulates ERK-2 expression. FRS3 likely interacts directly with GRB2, SH-PTP2, Flg, and Trk A, and may be involved in MAP kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGFR substrate 3; FGFR-signaling adaptor SNT2; Fibroblast growth factor receptor substrate 3; FRS2-beta; FRS3; SNT-2; Suc1-associated neurotrophic factor target 2; suc1-associated neurotrophic factor target 2 (FGFR signalling adaptor); testicular tissue protein Li 71
Gene Aliases: 4930417B13Rik; AI449674; FRS2-beta; FRS2B; FRS2beta; FRS3; SNT-2; SNT2
UniProt ID: (Human) O43559, (Rat) Q52RG8, (Mouse) Q91WJ0
Entrez Gene ID: (Human) 10817, (Rat) 316213, (Mouse) 107971
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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