This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
Immunogen sequence: TIESVADYFK QIGIIKTNKK TGQPMINLYT DRETGKLKGE ATVSFDDPPS AKAAIDWFDG KEFSGNPIKV SFATRRADFN RGGGNGRGGR GRGGPMGRGG YGGGGSGGGG RGGFPSGGGG GGGQQRAGDW KCPNPTCENM NFSWRNECNQ CKAPKPDGPG GGPGGSHMGG NYGDDRRGGR GGYDRGGYRG RGGDRGGFRG GRGGGDRGGF GPGKMDSRGE HRQDRRERPY; Positive Samples: U-937, Jurkat; Cellular Location: Nucleus
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
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Protein Aliases: 16) in malignant liposarcoma); 16) malignant liposarcoma; 75 kDa DNA-pairing protein; fus-like protein; fused in sarcoma; fusion (involved in t(12; fusion gene in myxoid liposarcoma; fusion, derived from t(12; fusion, derived from t(12;16) malignant liposarcoma; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; Oncogene FUS; Oncogene TLS; pigpen protein; POMp75; Protein pigpen; RNA-binding protein FUS; translocated in liposarcoma; Translocated in liposarcoma protein
Gene Aliases: ALS6; D430004D17Rik; D930039C12Rik; ETM4; FUS; FUS1; HNRNPP2; POMP75; TLS
Molecular Function: RNA metabolism protein