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Invitrogen
FUS Polyclonal Antibody
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Product Details
PA5-96477
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.82 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: TIESVADYFK QIGIIKTNKK TGQPMINLYT DRETGKLKGE ATVSFDDPPS AKAAIDWFDG KEFSGNPIKV SFATRRADFN RGGGNGRGGR GRGGPMGRGG YGGGGSGGGG RGGFPSGGGG GGGQQRAGDW KCPNPTCENM NFSWRNECNQ CKAPKPDGPG GGPGGSHMGG NYGDDRRGGR GGYDRGGYRG RGGDRGGFRG GRGGGDRGGF GPGKMDSRGE HRQDRRERPY; Positive Samples: U-937, Jurkat; Cellular Location: Nucleus
Target Information
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 16) in malignant liposarcoma); 16) malignant liposarcoma; 75 kDa DNA-pairing protein; FUS; fus-like protein; fused in sarcoma; fusion (involved in t(12; fusion gene in myxoid liposarcoma; fusion, derived from t(12; fusion, derived from t(12;16) malignant liposarcoma; heterogeneous nuclear ribonucleoprotein P2; hnRNP P2; nuclear RNA-binding protein; Oncogene FUS; Oncogene TLS; pigpen protein; POMp75; Protein pigpen; RNA-binding protein FUS; translocated in liposarcoma; Translocated in liposarcoma protein; unnamed protein product
Gene Aliases: ALS6; altFUS; D430004D17Rik; D930039C12Rik; ETM4; FUS; FUS1; HNRNPP2; POMP75; TLS
UniProt ID: (Human) P35637, (Mouse) P56959
Entrez Gene ID: (Human) 2521, (Rat) 317385, (Mouse) 233908
nucleic acid binding
DNA binding
chromatin binding
transcription cofactor activity
transcription coactivator activity
RNA binding
mRNA 3'-UTR binding
protein binding
zinc ion binding
identical protein binding
metal ion binding
molecular condensate scaffold activity
nucleotide binding
estrogen receptor binding
myosin V binding
ionotropic glutamate receptor binding
poly(A) RNA binding
retinoid X receptor binding
thyroid hormone receptor binding
RNA metabolism protein
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
RNA splicing
gene expression
regulation of RNA splicing
positive regulation of transcription, DNA-templated
mRNA stabilization
protein homooligomerization
membraneless organelle assembly
positive regulation of double-strand break repair via homologous recombination
amyloid fibril formation
biological_process
cellular response to calcium ion
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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