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Invitrogen
FUS Monoclonal Antibody (CL0190)
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Product Details
MA562968
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
CL0190
Immunogen
Recombinant protein corresponding to Human FUS
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
Target Information
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 75 kDa DNA-pairing protein; FUS; fus-like protein; fused in sarcoma; fusion gene in myxoid liposarcoma; heterogeneous nuclear ribonucleoprotein P2; nuclear RNA-binding protein; Oncogene FUS; Oncogene TLS; POMp75; RNA-binding protein FUS; Translocated in liposarcoma protein; unnamed protein product
Gene Aliases: ALS6; altFUS; ETM4; FUS; FUS1; HNRNPP2; POMP75; TLS
UniProt ID: (Human) P35637
Entrez Gene ID: (Human) 2521
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
RNA splicing
gene expression
regulation of RNA splicing
positive regulation of transcription, DNA-templated
mRNA stabilization
protein homooligomerization
membraneless organelle assembly
positive regulation of double-strand break repair via homologous recombination
amyloid fibril formation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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