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Bioss
FUSIP1 Polyclonal Antibody
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FIGURE: 1 / 2
FUSIP1 Antibody (BS-13229R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded rat testis tissue; Antigen retrieval by boiling in sodium citrate buffer(pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with Rabbit Anti-FUSIP1 Polyclonal Antibody, Unconjugated (bs-13229R) at 1:400 overnight at 4°C, followed by a conjugated secondary and ... View More
Product Details
BS-13229R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FUSIP1, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
FUSIP1 is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing.This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. Alternative splicing of this gene results in at least two transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 40 kDa SR-repressor protein; FUS interacting protein (serine-arginine rich) 1; FUS interacting protein (serine/arginine-rich) 1; Fus-associated protein with serine-arginine repeats; FUS-interacting protein (serine-arginine rich) 2; FUS-interacting serine-arginine-rich protein 1; Neural-salient serine/arginine-rich protein; neural-salient SR protein; Neural-specific SR protein; protein phosphatase 1, regulatory subunit 149; serine-arginine repressor protein (40 kDa); Serine/arginine-rich splicing factor 10; serine/arginine-rich splicing factor 13A; Splicing factor SRp38; splicing factor, arginine/serine-rich 13; Splicing factor, arginine/serine-rich 13A; SR splicing factor 10; SRrp40; TASR; TLS-associated protein TASR; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; TLS-associated SR protein
Gene Aliases: FUSIP1; FUSIP2; NSSR; NSSR1; NSSR2; PPP1R149; SFRS13; SFRS13A; SRp38; SRrp40; SRSF10; Srsf13a; TASR; TASR1; TASR2
UniProt ID: (Human) O75494, (Mouse) Q9R0U0
Entrez Gene ID: (Human) 10772, (Rat) 362630, (Mouse) 14105
spliceosomal tri-snRNP complex assembly
RNA splicing, via transesterification reactions
mRNA splicing, via spliceosome
regulation of transcription, DNA-templated
mRNA splice site selection
mRNA export from nucleus
cytosolic transport
regulation of mRNA splicing, via spliceosome
negative regulation of mRNA splicing, via spliceosome
mRNA processing
RNA splicing
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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